SLC25A32 is the mitochondrial carrier for the tetrahydrofolate (THF) species in mitochondrial one-carbon (1 C) metabolism, as demonstrated by in vitro studies 23 , mouse genetics 24 and cell culture characterization 25,26,27
Merino-Ramrez M, Bolton CF
The ability of the lung to utilize GSH from the plasma seems evident based on the fact that during the rest period the plasma GSH spikes at 4 hours while at the same time point the lung GSH is slightly higher and the ELF GSH is still rising
However, with IBD-current biologic therapies, all these mean some patients primary non-responders, experience a loss of response, intolerance or side effects, defining the urgent unmet need for novel treatments (13, 14)
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