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In addition, the CIA model also reproduces accurately the chronic and progressive course of RA as observed in humans (7880)

Published investigations report measurable biological signaling changes in controlled human or preclinical settings

A 2012 systematic review and meta-analysis, along with a 2013 controlled clinical trial, showed that ALA is an effective drug in the treatment of diabetic neuropathy, which affects about 50 percent of people with diabetes

1 Introduction Gout, a prevalent metabolic disorder characterized by hyperuricemic-induced monosodium urate (MSU) crystal deposition in joints and periarticular tissues, elicits intense inflammatory responses that cause significant morbidity ( Escherichia coli and Bacteroides ) that promote urate accumulation and inflammation ( In this review, we synthesized existing information on BA-gout interactions, highlighting: the mechanistic interplay between BA dysregulation and gout pathogenesis across metabolic, immune, and microbial axes

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