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In rats given BPC-157, serotonin levels in the brain increase in specific regions while simultaneously decreasing in other regions, such as the hippocampus.[ref] A 2020 study found that BPC-157 reduced leaky gut syndrome by stabilizing gut permeability after NSAID use.[ref] Reducing leaky gut theoretically can affect the gut-brain axis and reduce inflammation

However, there are some theories many (if not all) of which have to do with how the drug works

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Fourth, long-term clinical outcomes data - cirrhosis incidence, HCC rates, liver transplantation, and liver-related mortality assessed as primary endpoints in randomized trials - are not yet available and are urgently needed to move beyond surrogate histological endpoints

Your healthcare provider can determine if its a safe and appropriate option to manage your side effects while on GLP-1 treatment