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Recent advances in computational biology, particularly through the development of AlphaFold, have enabled the prediction of the structures of 98% of the human proteome 13,14

There is a need for local evidence-based guidelines to best manage patients on GLP-1RAs and dual GLP-1 and glucose-dependent insulinotropic polypeptide receptor co-agonists (GLP-1/GIPRAs) presenting for surgical and medical procedures requiring sedation or anaesthesia

J Nephrol 33(5):965975 Heusser K, Tank J, Diedrich A, Fischer A, Heise T, Jordan J (2023) Randomized trial comparing SGLT2 inhibition and hydrochlorothiazide on sympathetic traffic in type 2 diabetes