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This suggests a duration-dependent relationship, though it has not been confirmed in prospective studies designed specifically to test this question

Future studies aiming to assess the duration of the therapeutic efficacy and the optimal dose in larger populations, possibly with longer follow-up periods, are required

Medical writing assistance for this article, provided by Noa Chapman, MSc, and Kerris Chappell-Smith, BSc, Costello Medical, UK, was funded by Ipsen in accordance with Good Publication Practice (GPP3) guidelines ( Ethics declarations Ethics approval and consent to participate Not applicable

However, compliance and absorption variability mean injectable therapy remains preferred for confirmed deficiency in elderly patients