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Similarly, DHODH can reduce oxidized CoQ10 by converting ubiquinone to ubiquinol within the mitochondrial inner membrane, thereby inhibiting ferroptosis [51]

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Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)

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