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The most frequently reported adverse events involve gastrointestinal symptoms like nausea and constipation, which typically resolve within weeks

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These mood-related and motivational changes are not yet fully characterized in the clinical literature, though they appear linked to the drugs effects on dopaminergic and reward pathways beyond appetite regulation alone

These effects appear to be mediated in part through the recruitment and activation of fibroblasts, the primary collagen-producing cells in connective tissue

Most common for both protocols