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PMID: 38753454
gamma-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor
Basic six therapeutic principles of IEM include: (1) substrate reduction therapy (as in PKU), (2) removal of toxic metabolites (e.g., urea cycle disorders), (3) product supplementation (e.g., cerebral creatine deficiency disorders), (4) stimulating of deficient enzyme activity (e.g., B 6 supplementation in CBS deficiency), (5) enzyme replacement therapy (e.g., in LINCL) or 6) organ transplantation (in some cases of UCD and AIP)
Exendin-4 (Exenatide) mimicks GLP-1 but is much more potent in vivo following parenteral administration (28)
Is she having symptoms of hormonal decline
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