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Overall, these findings indicate that targeting both GIPR and GLP-1R in the CNS with peptideantibody conjugates, enabling GIPR blockade together with GLP-1R agonism, enhances weight loss

Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Baar et al., 2017)

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In preclinical and clinical studies, cagrilintide thereby showed a stable plasma concentration over seven days

Ongoing studies are investigating whether ipamorelin can aid in fat loss in individuals struggling with obesity or metabolic disorders like insulin resistance or type 2 diabetes