GLP-1RA also increased glucose-stimulated insulin secretion (GSIS) and islet insulin content and reduced triglyceride content in islets
Water retention and inflammation also increase the upward pressure
In practice, providers may find that Wegovy has a more established approval pathway, while Zepbound, being newer and more costly, can face more complex or inconsistent payer scrutiny
They include: Semaglutide ( Wegovy ): A GLP-1 agonist, which triggers hormonal activity to keep blood sugar low, reduce cravings, and increase feelings of fullness
Summary Keywords glucagon-like peptide 1 receptor agonist, type 2 diabetes, cardiovascular, safety, semaglutide Citation Nauck MA and Quast DR (2021) Cardiovascular Safety and Benefits of Semaglutide in Patients With Type 2 Diabetes: Findings From SUSTAIN 6 and PIONEER 6