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I f our hypothesis is correct, it may be possible to further improve the symptoms by suppressing the production of proinflammatory cytokines and, thereby, restoring the normal astroglial glutamate uptake. It goes without saying that exacerbation of symptoms in response to physical or mental stressors is as emblematic of ME/CFS as the PEM that follows and that, by definition (with most case definitions requiring new onset fatigue of at least 6 months duration), in ME/CFS mental fatigue may have already become a chronic condition

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therefore, arginine dystrophy is also present

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