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We propose that both passive and active intravasations occur as tumor progresses, since the surrounding extracellular matrix (ECM) is degraded and enables both EMT and non-EMT tumor cells to intravasate into circulation ( Figure 3 ) (74, 75)

J Cell Physiol 233(4):30553065

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The peptide's primary function may not ultimately be sleep at all, although it is most closely associated with sleep cycle regulation, because DSIP levels are the same in CNS tissues as in peripheral tissues, suggesting that the peptide may also be formed outside the CNS

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