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Plasma cholesterol and depressive symptoms in older men Lancet 1993

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If lifestyle habits slip over time, weight loss may slow or stop, and it may seem like the medicine is less helpful

They May Help If You: Follow a calorie-controlled diet Exercise regularly Use the patch consistently Need support with cravings or snacking habits They May Not Help If You: Expect dramatic results without lifestyle changes Use low-quality or untested products Have hormonal or medical causes of weight gain Prescription GLP-1 medications generally have stronger clinical evidence compared to over-the-counter patches