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Ethics Approval and Consent to Participate The experimental protocol received approval from the Institutional Research Board of Batterjee Medical College, Jeddah (RES-2025-0017)

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474 Inhibition of TLR4/NOX4 significantly improves left ventricular remodeling by inhibiting ferritinophagy, confirming the critical role of ferritin-mediated ferroptosis in the development of cardiac hypertrophy and heart failure