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Common side effects include nausea, vomiting, and constipationespecially during dose escalationbut these usually improve over weeks

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Characterization of overt hyperglycemia in insulin receptor mutant ( Insr P1195L/ +) mice exposed to HFD ( Insr P1195L/ +/HFD mice) revealed increased glucose-6-phosphatase ( G6pc ) expression in liver and increased gluconeogenesis from glycerol