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Yerba mate is unlikely to cause harm to healthy adults who drink it occasionally
No human trial has shown Akkermansia to be a weight-loss treatment, and the same trial did not meet its main insulin-sensitivity goal across the group as a whole, with benefits showing up mainly in people who started with low Akkermansia levels or who had prediabetes
Free Radic Biol Med (2021) 177:15666
Continuous use without rest periods is not recommended
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, leads to altered carbohydrate metabolism in cancer cells
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