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their mRNA or protein levels may serve as positive indicators of ongoing lipid remodeling and peroxidation ( 2.5.3 Ironhandling molecules Ferritin, transferrin saturation, and labile iron pool measurements in serum or BALF reflect systemic and alveolar iron loading ( NCOA4 expression in airway epithelial cellsassessed by qPCRmay indicate enhanced ferritinophagy and intracellular iron release ( 2.5.4 Ferroptosisrelated gene signatures Transcriptomic analyses of IPF BALF have identified an eightgene ferroptosis signature (NRAS, EMP1, SLC40A1, MYC, ANGPTL4, PRKCA, MUC1, GABARAPL1) that distinguishes IPF patients from healthy controls and associates with prognosis

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