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Importantly, it has been demonstrated that iron overload could potentiate the inflammatory response of macrophages to LPS possibly by disrupting mitochondrial homeostasis and increasing the production of mitochondrial superoxide [105]

In patients with T2DM who do not have atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss, GLP-1 RAs are generally recommended as a second or third-line option as add-on to metformin therapy

Frequency: one subcutaneous injection 5 days per week , titrating up as tolerated [5] [6]

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