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Sumala S, et al

These findings have positioned GLP-1s as a preferred second-line treatment option after metformin, particularly in patients with established heart disease

(2.1) The recommended starting dose in patients not currently treated with metformin is 100 mg sitagliptin and 1000 mg metformin HCl once daily, with gradual dose escalation recommended to reduce the gastrointestinal effects due to metformin

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