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The downstream effects are dramatic: keratinocyte proliferation and differentiation accelerate, the epidermis compacts and normalizes, melanin transfer is disrupted (fading pigmentation), and dermal fibroblasts are stimulated to produce new collagen while matrix-degrading enzymes (MMPs) are suppressed

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J Neurosci 28:1359213608 [DOI] [PMC free article] [PubMed] [Google Scholar] Yuste R, Bonhoeffer T