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Similarly, the GIPR rs1800437 variant impacts glucose-dependent insulinotropic polypeptide signaling, another hormone pathway that works alongside GLP-1 to regulate appetite and metabolism

In SURMOUNT-1, people who had 10mg as their stable dose lost 19.5% of their body weight on average after using Mounjaro for 72 weekswhich translated into a mean loss of 22.2kg

JAMA Netw Open 2022;5:e2231982

Industry experts see steady growth in the market for GLP-1 medications for the next decade

However, in other organs the number of immune cells containing GLP-1 receptors is negligible, indicating another mechanism to be at play