The 24 top-ranked hits with ROCS combo scores from 1.93 to 1.29 were selected considering their molecular shape, chemistry, electrostatic parameters, and the predicted binding interactions into the more diverse PbGST H-site (Supplementary Figure S5)
J Biol Chem 280(31):2849828506 Villard E, Perret C, Gary F, Proust C, Dilanian G, Hengstenberg C, Ruppert V, Arbustini E, Wichter T, Germain M, Dubourg O, Tavazzi L, Aumont MC, DeGroote P, Fauchier L, Trochu JN, Gibelin P, Aupetit JF, Stark K, Erdmann J, Hetzer R, Roberts AM, Barton PJ, Regitz-Zagrosek V, Aslam U, Duboscq-Bidot L, Meyborg M, Maisch B, Madeira H, Waldenstrm A, Galve E, Cleland JG, Dorent R, Roizes G, Zeller T, Blankenberg S, Goodall AH, Cook S, Tregouet DA, Tiret L, Isnard R, Komajda M, Charron P, Cambien F (2011) A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy
bioRxiv , 2021.2009.2028.462109 (2021)
Possible applications being studied: An asthma is a disease associated with chronic inflammation of the airways which causes breathing difficulties as well as hypersensitivity of the airways
Study location, treatment duration and type of control were detected as sources of heterogeneity following subgroup analysis (Table 2)
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