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moderate (CCI 12)

About half of individuals who undergo cholecystectomy experience digestive symptoms such as loose stools, gas, and bloating following surgery

Also, small molecule PAMs of GLP-1 have been found that can potentiate the action of GLP-1 (7-36) and its metabolite GLP-1 (9-36), which retains some weak activity (EC 50 = 1.8 M, E MAX = 13%) for GLP-1R

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