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Contraindications & Precautions Pregnancy, lactation (insufficient data), known hypersensitivity

Treating the metabolic conditions becomes part of treating the osteoarthritis. Research has shown that patients with type 2 diabetes are more likely to have severe osteoarthritis as well as a higher likelihood of needing revision surgeries after knee replacements

Seccombe, D

GLP-1 RAs have been shown by Herman & Schmidt [] to decrease nicotine-induced dopamine release in the nucleus accumbens, which attenuates the reinforcing effects of nicotine and may lessen cravings and the chance of relapse []