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Several studies, including analyses from large-scale datasets such as the National Health and Nutrition Examination Survey (NHANES), have identified surrogate markers related to IR that could potentially facilitate early risk assessment for ED

10.1016/j.neuron.2012.03.023 271

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GSNO is metabolized by the NADH-dependent GSNOR, which thereby shifts the cellular equilibrium to disfavor protein SNOs, while Trxs and TrxRs denitrosylate proteins directly