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Most formulations must strictly adhere to USP (United States Pharmacopeia) standards to guarantee maximum purity levels

IL-6 is an independent predictor of survival in patients with PH, IL-1 can stimulate IL-6 production and promote the muscularization of distal small arteries [53], TNF- can increase pulmonary artery pressure and pulmonary vascular remodeling [54], while IL-10 can protect against PASMC proliferation and prevent progression of PH [55]

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DNA alkylating agents: pyrrolobenzodiazepine (PBD) dimers and duocarmycin (DCM) DNA alkylation distorts the DNA helix and promotes insertion of incorrect nucleotides, impairing DNA repair, replication, transcription, and ultimately inducing apoptosis 46