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Joosten, M

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(2018) 3(24):e120360

Therefore, studies have investigated how CHAC1 is regulated in tumor cells and their microenvironment: Prostate cancer patients frequently develop resistance to docetaxel, a challenge in which cancer-associated fibroblasts (CAFs) have been shown to play a significant role through exosome-mediated signaling ( In gastric cancer, the RNA demethylase ALKBH5 (Alkylated DNA repair protein alkB homolog 5) removes an m 6 A modification from CHAC1 mRNA, a mark normally associated with transcript stability