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In a Complete Response Letter, the regulator stated that Aldeyras New Drug Application did not demonstrate efficacy in treating ocular symptoms associated with dry eyes and informed the company that at least one additional adequate and well-controlled study would be required to demonstrate efficacy

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H 2 S, for example, can bind to protein metal centres, such as haem moieties in mitochondrial cytochrome c oxidase or haemoglobin (reviewed e.g

Dendritic arborization analysis To assess dendritic arborization, 5 10 5 primary cortical neurons were cultured on 13 mm glass coverslips