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These minor changes are often made solely to create the illusion that the patient requires a unique compounded formulation when, in reality, they do not. Whats particularly telling is that many compounding pharmacies are offering the same additives or minor adjustments to large numbers of patientsi.e., mass personalizationwhich clearly demonstrates a violation of FDA requirements for individualized compounding. FDA, Eli Lilly and Novo Nordisk Agree on Compounded GLP-1 Medications The FDA makes it clear: providers should not sell or market compounded GLP-1 medications like semaglutide and tirzepatide unless a patient has a legitimate, documented clinical need

Lancet 2002;359:891

Patients with chronic pain who are considering GLP-1 therapy should discuss their full pain management picture with their provider

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Patients should be aware of the need to have a readily available source of glucose (dextrose, d-glucose) or other carbohydrate to treat hypoglycemic episodes