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2.1.1 System Xc - Solute carrier family 7 member 11 (SLC7A11, catalytic subunit) and solute carrier family 3 member 2 (SLC3A2, regulatory subunit) make up System Xc- ( The antioxidant response is mediated by NRF 2, a master transcription factor

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In a 2021 metaanalysis of cardiovascular outcome RCTs published by Sattar et al., GLP1RAs significantly reduced the risk of a composite kidney outcome consisting of the development of abnormal albuminuria, doubling of serum creatinine, or at least a 40% decline in eGFR, kidney replacement therapy, or kidneyrelated death by 21% (HR 0.79