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4 Unfortunately, the general but insurmountable problem is that neither of the supposed mediators when applied as a therapy could realize in practice the full theoretical assumption that homeostasis could be achieved

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They fully utilize the unique targeted antioxidant effect of ergothionein directly to the mitochondria, accurately removing free radicals inside and outside the cell, while repairing the damage of free radicals to chromosomes, enhancing skin whitening and radiance, stimulating collagen regeneration, improving sleep quality, and truly achieving comprehensive antioxidant and anti-aging effects with high efficiency

Levring et al., 2015)

The only published human data are from 12 patients with interstitial cystitis (2024) and 2 healthy subjects (2026)