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ERS activates the protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (PERK)/eukaryotic translation initiation factor 2 (eIF2)/activating transcription factor 4 (ATF4) pathway, upregulating the pro-apoptotic protein C/EBP homology protein (CHOP), suppressing Bcl-2 expression, and activating Caspase-12 (replaced by Caspase-4 in humans)a pro-apoptotic branch of the unfolded protein response (UPR) [15]

[DOI] [PubMed] [Google Scholar] 337.Watson WH

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The amino group is removed from the amino acid and converted to ammonia