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To investigate the mechanisms by which ibuprofen affect mouse liver, a quantitative LC-MS/MS technique using tandem mass tag (TMT) labeling was carried out to measure whole liver proteome changes after short-term (7 days) treatment of ibuprofen (100 mg/kg/day)

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intermittent treatment with senolytics have conclusively reduced senescent cell burden in peripheral tissues (fat, lung, kidney, pancreas, cartilage, and muscle), improved pathologies in these tissues, and extended healthspan and lifespan (45, 46, 100-103)

10.1016/j.lfs.2005.07.003 Life Sci

DOI:10.2174/1381612811306010076 2