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For most researchers, the two-compound stack represents a clean, manageable protocol without the complexity of managing multiple compounds simultaneously

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Indeed, in 1988 Bannai reported glutamine import via ASCT2 and conversion into glutamate that is exported in exchange of cystine import (1:1) via xCT (45)

Furthermore, it has been observed that over 60% of patients suffering from type 2 diabetes mellitus (T2DM) also exhibit metabolic aberrations suggestive of MASLD