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doi:10.1097/PRS.0000000000009876

Rigobello MP, Messori L, Marcon G, Agostina Cinellu M, Bragadin M, et al

PMID: 29986520 Pickart L

In reproductive tissues, peptides may originate endogenously, released during normal physiology or injury, or from exogenously applied preparations intended to simulate or stimulate those signals

The constitutive active sites are 1, 2, and 5 that are responsible for caspase-like (C-like), trypsin-like (T-like), and chymotryptic activity (CT-like), respectively