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Experimental work described by Patt et al

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These enzymes mediate the response to cellular stress, inducing metabolic changes by regulating the activity of proteins such as PGC1 (PPAR coactivator-1) (Chalkiadaki and Guarente, 2015), which is a master in the regulation of mitochondrial metabolism and an activator of genes associated with the oxidation of fatty acids (Mattes et al., 2019)