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It is thought that bioactive peptides derived from whey proteins as a result of gastrointestinal digestion or bioactive peptides in the whey protein mixture with antioxidant properties may also play a role in improving liver and kidney damage caused by MTX

Glutathione synthesis plays key roles in the formation of TLS, and a specific metabolic pathway in a limited cell population within TLS determines the outcome of the formation of TLS

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Although described here as pools for conceptual simplicity, NAD and NADPH are not uniformly distributed but are frequently associated with specific enzymes or enzyme complexes, enabling localized and pathway-specific redox regulation

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