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The mechanisms through which probiotics exert their effects are multifaceted, encompassing optimization of gut microbiota composition, enhancement of beneficial bacterial populations, protection of the intestinal barrier, inhibition of pathogen invasion to prevent endotoxemia, reduction of oxidative stress, modulation of immune responses, suppression of pro-inflammatory cytokines, promotion of anti-inflammatory cytokines, and augmentation of the production of beneficial metabolites ( Prominent examples of probiotic supplements include the genera Lactobacillus and Bifidobacterium

These findings on liver-fat mobilization in people without diabetes enrolled in the study are impressive because no other medication currently has labeling from the FDA for the indication of reducing excess liver fat

These reductions were significant with or without excluding outlier datasets

As mentioned above, the nomenclature NAFLD has been changed, first to metabolic (dysfunction)-associated fatty liver disease (MAFLD) [57] and more recently to metabolic dysfunction-associated steatotic liver disease (MASLD) [2]

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