Nausea, Bloating, and Discomfort One of the most common side effects of GLP-1s is gastrointestinal discomfort including nausea, indigestion, and bloating
It occurs after a period of successful weight loss
Novel GLP-1R agonists currently under development include HRS9531, a dual GLP-1/GIP receptor agonist being evaluated in overweight or obese individuals with T2DM, which has shown promising results in a Phase 2 study [172]
Animal Model:NZB/NZW mice, immune nephritis model [3] Dosage:5 mg/kg/day Administration:Oral, 6 days a week for 72 weeks Result:Significantly lowered mortality rate and prolonged life significantly
A systematic review and meta-analysis of randomized controlled trials focusing on the impact of L-Carnitine on adult weight loss revealed that subjects who received L-Carnitine supplementation lost significantly more weight and showed a decrease in body mass index (BMI) compared with those who did not receive the supplement