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In the case of glucocorticoids, both excess (Cushings syndrome) and insufficiency (Addisons disease) contribute to oxidative stress through a variety of mechanisms, such as decreased antioxidant defenses, increased reactive oxygen species (ROS) generation, and impaired mitochondrial function, which ultimately results in chronic inflammation
They slow gastric emptying, prolong satiety, and may dampen neural reactivity to food cues that trigger binge episodes
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Another study replicated the results when researchers gave different doses of ipamorelin subcutaneously three times a day for 15 days to rats under observation
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doi: 10.1080/1028415X.2017.1344371 138
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