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State Key Laboratory of Genetic Resources and Evolution, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China 2

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Characterized Signaling Pathways Published research has identified multiple receptor-mediated signaling interactions: MC1R / Melanogenesis (cAMPPKAMITF Axis) MT-2 binds MC1R with high affinity, activating Gs-coupled adenylyl cyclase and elevating intracellular cAMP