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In the presence of T3, TRs interact with coactivators like TRAP (thyroid receptor-associated protein), which increases gene transcription
Since most melanotic macules do present on the lip, patients often request complete removal due to esthetic concerns
Indeed, although IIEF-6 is a validated questionnaire distinguishing between presence or absence of ED by considering the whole spectrum of aspects related to penile erectile function, and also grading the severity of ED in clinical setting, it still remains a subjective tool, prone to the risk of recall bias, patients emotional drawbacks or patients conditioning due to uneasiness or misinterpretation of questions
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