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nih Jastreboff A.M., Kaplan L.M., Fras J.P., Wu Q., Du Y., Gurbuz S., Coskun T., Haupt A., Milicevic Z., Hartman M.L

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The results showed that treatment with chestnut leaf extract reduced the expression ratio of Bcl-2 and Bax, and an increase in the amount of cleaved PARP and paclitaxel-treated CSCs resulted in significant mitochondrial damage compared to untreated or extract-treated CSCs

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In the study where they found that oxidizing cholesterol increased its ability to cause atherosclerosis in rabbits, they heated the cholesterol for eight hours