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[3] Patients should report symptoms such as new shortness of breath, chest pain, syncope, or leg swelling immediately

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Key assumptions and uncertainties The results discussed earlier depend on several key assumptions and how they may change over time: How many people take the drug How effective the drug is at reducing BMI How much the drugs reduce mortality risk beyond their impact on BMI How long people persist in taking the drug How much and how quickly weight is put back on for those who stop taking the drug How many eligible people take the drug and for how long depends mainly on cost, including insurance coverage, side effects, and how much and how quickly weight is lost