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officinarum was shown to possess an anti-inflammatory effect in LPS-activated mouse RAW 264.7 macrophages and human PBMCs in vitro (Yadav et al., 2003) HMP at the concentration range of 6.2525 M significantly reduced the NO level in the mice macrophages and IL-1 and TNF- levels in PBMCs in a dose-dependent pattern

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The active site of the enzyme that binds glycine to the dipeptide -L-glutamyl-L-cysteine is highly specific (57)