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According to prescribing information, the oral Wegovy pill must be taken once daily on an empty stomach with a small amount of water, followed by a 30-minute waiting period before eating, drinking, or taking other medications

Conversely, when Clostridium bolteae derived UDCA and GUDCA act as FXR antagonists, they relieve FXR-mediated repression of the proglucagon gene (Gcg), upregulate glycolytic enzymes phosphofructokinase 1 and enolase 1 to increase ATP production, and additionally stimulate proliferation of Lgr5 intestinal stem cells and effectively expand the pool of GLP-1secreting L cells rather than merely increasing output per cell

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