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SAM then donates a methyl group to several acceptor molecules (e.g., DNA, RNA, proteins, metabolites), generating S-adenosylhomocysteine (SAH), which is then hydrolyzed to homocysteine and adenosine, in reactions catalyzed by methyltransferases (MT) and adenosylhomocysteinase (AHCY, SAH hydrolase), respectively (Figure 1
