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Dormancy Period: 2 months up to several years

Rationale: MOTS-c's insulin-sensitizing and glucose disposal effects become most relevant when carbohydrate intake creates glucose disposal demands

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Participants with obesity (a body-mass index [BMI] of 30) and a clinical and radiologic diagnosis of moderate knee osteoarthritis with at least moderate pain were randomly assigned 2:1 to receive once-weekly subcutaneous semaglutide (2.4 mg) or placebo, in addition to counseling on physical activity and a reduced-calorie diet