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A 2024 study published in the International Journal of Retina and Vitreous found that using a semaglutide medication like Wegovy more than doubled the risk of NAION over five years

Reported effects with this class include mild water retention, transient tingling or numbness in the hands, a brief flushing or head-rush sensation after injection, and increased hunger with some secretagogues

doi: 10.1186/1475-2875-9-350 49 TotinoP

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This reaction forms 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine (SAH)