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Suramin (100 M) was found not to be suitable for this experiment because it triggered a Ca 2+ response in 75% of GLUTag cells (mean SEM 340/380 ratio of responsive GLUTag cells = 0.7 0.1, n = 15) and did not completely block exogenous ATP-triggered calcium responses in ND neurons (56 5% block, n = 22

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However, this exclusivity can be extended by regulatory mechanisms such as patent term extensions or exclusivity granted by the FDA

This hormone plays a critical role in appetite regulation and glucose metabolism

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